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The Golgi apparatus and sur-rounding regions ofthe cytoplasm contain numerous vesicleswith a flocculent content that is presumed to consist ofmatrixprecursors. ( a) An upright abdominal radiographdemonstrates linear intramural air shadows ( arrows) in the ascendingand hepatic ?exure colon. Thisprocess is termed as mucociliary escalator mechanismand typically completed with 24–48h. Many of ourmodern drugs, such as digitalis, atropine, and opiate derivatives like mor-phine and codeine, are highly toxic if used inappropriately, and somecan lead to dependency
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A simple illustration of Paracelsus’sadmonition and how it applies to all substances is seenFigure 1.2.