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Recognitionthat AD pathology was the most common pathology under-lying late-life dementia and the lack of definitive criteria fora pathologic diagnosis of vascular dementia resulted in alesser emphasis on vascular dementia as a pathologic sub-strate for age-related dementia. It is oflittle value in most acute and short-livedinfections. Peripheral nerves PGs (especially E2 andI2) sensitize afferent nerve endings to pain inducingchemical and mechanical stimuli (Fig.
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