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The VITAmins TO Prevent Stroke (VITATOPS)trial showed that daily administration of folic acid, vita-min B6, and vitamin B12 to patients with recent stroke ortransient ischemic attack was safe but did not seem to bemore effective than placebo in reducing the incidence ofmajor vascular events (composite of stroke, myocardialinfarction, or vascular death) (VITATOPS Trial StudyGroup, 2010). Measure the diagonalconjugate by pressing internal hand into thesacral promontory and up; mark the spot onyour hand directly below the symphysis pubis(Fig

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