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12.4 Relationship between altitude, barometric pres-sure, pressure of inspired oxygen (PIO2), PaO2, and SaO2(Adapted with permission from Hackett et al. Spectrum of musculo-skeletal disorders in sicklecell disease in Lagos, Nigeria.

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Thewall ofthe microtubule is approximately 5 nm thick and consists of13 circularly arrayed globular dimeric tubulin molecules.The tubulin dimer has a molecular weight of 110 kDa and isformed from an a-tubulin and a P-tubulin molecule, eachwith a molecular weight of 55 kDa (Fig. It is a dynamic processwith respect to both lineage decisions and origin duringdevelopment.