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When the SSRIs emerged in the early 1990s Peter Kramer in hiswell-known Listening to Prozac was an advocate of that wide market for these drugs (Kramer1993). These TCRs function in a similar way to traditional TCR in that they activate theT cell they are inserted into and have the ability to mediate antigen-specific T cellcytotoxicity. A freshview of these issues, a change in current philosophy, lead-ing to new and different, multimechanistic methods of pre-vention may be needed.

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While lately, the increasein TB case rate associated with HIV infectionhas been halted in the USA, no such trend isapparent in India; out of all fresh TB cases, 1.2%are coinfected with HIV.

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