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Bloodvesselsand perivascu-larcells invadethe proximal epiphyseal cartilage (6),and a secondarycenter ofossification isestablished in the proximal epiphysis (7).A similar epiphyseal(secondary)ossificationcenter forms at thedistalend ofthe bone (8), andanepiphyseal cartilage isthus formed between eachepiphysisandthe diaphysis.With continued growth of the long bone, the distal epiphyseal cartilage disappears (9), and finally, with cessation of growth, the proximal epiphysealcartilage disappears (10).The metaphysisthen becomes continuous with the epiphysis. A special thanks goes to Crystal Taylor, Senior Acquisition Editor, for her supportthroughout the development of this book

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