Genotoxic agents directly targetthe dNA by causing single-strand and double-strandbreaks; whereas, epigenetic toxicants do not alter the dNAsequence but rather cause changes in methylation patterns.In animal studies, testicular toxicants that have beenshown to induce epigenetic changes in male germ cells arethe fungicide, vinclozolin, and the pesticide, methoxy-chlor (MxC)

Genotoxic agents directly targetthe dNA by causing single-strand and double-strandbreaks; whereas, epigenetic toxicants do not alter the dNAsequence but rather cause changes in methylation patterns.In animal studies, testicular toxicants that have beenshown to induce epigenetic changes in male germ cells arethe fungicide, vinclozolin, and the pesticide, methoxy-chlor (MxC). Unfortunately,calibration procedures are sometimes given short shrift in a journal article.

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