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For example, such an assumption legitimizes theidea that prisons can and should remain brutal for the normal prisoner (which is open to challenge)and that a health disposal will not be brutal (which empirically is not defensible).

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Thisnetwork of pathways argues against any version of a sin-gle primary pathway being responsible for CR effects, andsuggests a highly pleiotropic phenotype, consistent withother evidence that adaptive growth processes must be, bynecessity, sensitive to a host of signals (see Section Mam-malian Target of Rapamycin).

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